Objectives: To analyse the prescribing trends in haemodialysis patients and to assess QOL in haemodialysis patients with reference to their physical, psychological, social and environmental health dimension. Material and Methods: After taking approval from the Institutional ethical committee, a cross-sectional study was conducted in patients undergoing haemodialysis at Dialysis centre of tertiary care teaching hospital, over a period of three months. Rationality of prescription was analysed by comparing with WHO core drug prescribing indicators. WHOQOL-BREF questionnaire was used to assess the different domains of quality of life of haemodialysis patients. Data was analysed using statistical methods such as Kolmogorov Smirnov (KS) test, unpaired t-test and Analysis of Variance, Pearson correlation coefficient, SPSS version 18 and 20. Results: A total of 84 cases were analysed during the study, of which 65 were males and 19 were females with a mean age of 53.89 ± 13.34 years and 39.05 ± 8.45 years, respectively. Analysis of WHO core drug prescribing indicators showed that the average number of drugs prescribed per patient was 4.73, percentage of drugs prescribed by generic name was 39.62%, percentage of patients with an injection prescribed was 100%, percentage of drugs prescribed from essential medicine list was 41.5% and none of the patient was prescribed with antibiotic. Anticoagulant agent (100%) was the most commonly used drug, followed by antihypertensive drugs (94%), ulcer protective, calcium salt, multivitamins, erythropoietin, insulin, antiplatelet, oral hypoglycaemics and statins. Patients on haemodialysis had a poorer QOL in all domains except for domain 4 (environment). Domain 1 was highly correlated with domain 2 and moderately correlated with domain 3 and 4 with significant P value at 0.01. Conclusion: Current study provides valuable insight about the overall pattern of drug use profile in haemodialysis population. Heparin and amlodipine was the most commonly used drugs. We also found that QOL was very poor; especially low score was seen with physical and psychological domains.
Key words: Chronic Kidney Disease, Drug Utilization Studies, Hemodialysis, WHO core prescribing indicators, WHOQOL-BREF.